Dr. Siby Gopinath

Dr. Siby Gopinath is a clinical neurologist, epileptologist, and electrophysiologist working since 2001 Amrita Institute of Medical Sciences, Kochi. She completed her neurology residency from Amrita Institute of Medical Sciences, Kochi. Her special interest is in epilepsy sub-specialty, neuroelectrophysiology and sleep medicine. She underwent a specialised overseas training in epilepsy in Cleveland Clinic, Ohio and Toronto West Hospital, Canada. With this background she developed state-of-the-art Amrita Advanced Centre for Epilepsy (AACE) and Sleep Medicine, which subsequently became the largest epilepsy monitoring centre in the country and the first centre in the country to start a stereo-EEG program. It remains a centre with the highest number of stereo-EEGs done in the country. Stereo EEG is a minimally invasive technique (meaning not requiring open brain surgery) for recoding electrical activity from the brain and also for mapping the seizure and brain functions. She is currently Professor of Neurology and the director of Adult division of Epilepsy unit, at Amrita Advanced Centre for Epilepsy and Sleep medicine. She treats patients with epilepsy and has expertise in the management of patients with medically refractory epilepsy. Epilepsy surgery remains the mainstay of treatment for this difficult to treat group of epilepsy patients. She plays an integral role in the surgical treatment of epilepsy. Apart from the medical and surgical management, she is also experienced in treating epilepsy with dietary modifications (ketogenic diet), Deep Brain Stiumulation and minimally invasive surgical technique like radiofrequency ablation (a technique similar to Laser therapy).

She did her neurology residency from Amrita Institute of Medical Sciences, Kochi. She has a special interest in epilepsy sub specialty, neuroelectrophysiology and sleep medicine. She underwent a specialised overseas training in epilepsy in Cleveland Clinic Ohio and Toronto West Hospital, Canada. She also underwent a short training in high-density EEG from University Hospital, Geneva under Dr. Margitta Seeck.

She has multiple publications in national and international journals. She has been invited as a speaker in various national and international conferences. She has received travel bursary for World Epilepsy Congress held at Montreal. She has been a guide to 10 DM Neurology students, several post-doctoral fellows in epilepsy (2 fellows every year), program director for multiple undergraduate and postgraduate students of neuroelectrophysiology. She contributes as an external expert for the post-doctoral Epilepsy fellowship at Nizam’s Institute of Medical Sciences, Hyderabad. She has a vast experience in electroencephalography, and is currently working in advanced EEG techniques including high-density EEG and electrical source localisation. She has a huge experience in stereo-EEG (intracranial EEG), and is involved in the projects for developing computational analysis of stereo-EEG. She also has a vast experience in functional brain mapping including seizure mapping, functional mapping, neurostimulation techniques. She has successfully established the intra-operative neurophysiology program. Her current research interests involve post-processing analysis of neuroimaging including neuromorphometry, asymmetric PET subtraction, SISCOM. She is currently working on multiple clinical epilepsy projects in collaboration with other centres of the country. She is also in-charge of the Sleep Laboratory at Amrita Institute of Medical Sciences, Kochi and has worked for projects in narcolepsy and sleep apnea.

• Amrita Journal of Medicine; 2007: Nasal cure for myopathy - A neuroendocrine puzzle? Siby Gopinath, Syam UK
• Indian Journal of Dermatology Venereology and Leprology; 2009;75;307-309; Isomorphic and Isotopic phenomenon occurring simultaneously in a case of granuloma annulare; Feroze Kaliyadan1, Siby Gopinath2, MG Jayasree3, Chirag Parmar3
• Neurology India 2011: Vol: 59: Issue 6: Page 909-911Infectious psychosis: Cryptococcal meningitis presenting as a neuropsychiatry disorder: Anil Kumar, Siby Gopinath, Kavitha R Dinesh, Shamsul Karim
• Childs Nervous System (2011) 27:1766-67. (Abstract published): A comprehensive approach to the management of birth injuries of the brachial plexus. Pillai A, Vijayaraghavan S, Kishore P, Gopinath S, Roy AG, Surendran K, Ranjit TC.
• Contemporary Clinical Dentistry 2014: Vol5/ issue 4: Pages 489-494: Effect of rapid maxillary expansion on sleep characteristics in children: Navya Ashok, Sapna Varma N. K., Ajith V. V., Siby Gopinath
• Contemp Clin Dent 2015; 6:341-347: Efficacy of custom made oral appliance for treatment of obstructive sleep apnea. VR Cilil1, NK Sapana Varma1, Siby Gopinath2, VV Ajith1
• International Journal of Surgery 2016 Dec 1;36:466-76: Seizure outcome following primary motor cortex-sparing resective surgery for perirolandic focal cortical dysplasia Gopinath S, Roy AG, Puthanveetil VK, Sarma M, Kannan R, Pillai A.
• Neurology India March 2017: 65(S1): 34-44: Role of magnetoencephalography and stereo-electroencephalography in the presurgical evaluation in patients with drug-resistant epilepsy : Ashok Pillai, Siby Gopinath, Kurupath Radhakrishnan DOI: 10.4103/0028-3886.201680
• A Cross-sectional, Multicenter Study to Determine the Socio Expanding spectrum of contactin-associated protein 2 (CASPR2) autoimmunity-syndrome of parkinsonism and ataxia. Kannoth S, Nambiar V, Gopinath S, Anandakuttan A, Mathai A, Rajan PK.Neurol Sci. 2018 Mar;39(3):455-460. doi: 10.1007/s10072-017-3222-0. Epub 2017 Dec 20.
• Indian Journal of Sleep Medicine 2015/Vol 10/ 2/74-78: Clinical profile of narcolepsy in children in India Roy Arun Grace, Gopinath Siby, Kumar Suresh, Singh Dinesh, Nampoodiri Sheela, Vinayan KP, Kumar Anand, Einen MaliA, Mignot Emmanuel
• Annals of Indian Accademy of Neurology 2017/ 20/3/248-251: Delayed orthostatic hypotension: A pilot study from India. Arun Grace Roy, Siby Gopinath, Suresh Kumar, Sudheeran Kannoth, Anand Kumar.
• Epileptic Disord 2017; 19 (4): 456-60 A case of post-leptospirosis autoimmune epilepsy presenting with sleep-related hypermotor seizures. Prashant Makhija, Siby Gopinath, Sudheeran Kannoth, Kurupath Radhakrishnan
• International Journal of Medical Research and Review: February, 2018/ Vol 6/Issue 02 Use of cutaneous silent period parameters as a diagnostic indicator in patients with restless legs syndrome-a study in south Indian population: Alexander R., Saraswathy L, Gopinath S.
• Comparison of clinical and electrophysiological characteristics of ictal asystole and cardiac asystole encountered during video-electroencephalographic monitoring": Epileptic Disord. 2019 Aug 1;21(4):337-346. doi: 10.1684/epd.2019.1085 Sankaranarayanan, Muthukani; Makhija, Prashant; Gopinath, Siby; Mathew, Navin; Radhakrishnan, Kurupath
• Epileptic nystagmus due to a large parieto‐temporo‐occipital multilobar dysplasia. Epileptic Disorders. 2020 Oct;22(5):691-2.Jayakumar H, Gopinath S, Pillai A, Kumar A.
• Impact of COVID-19 pandemic on epilepsy practice in India: A tripartite survey. Rathore C, Baheti N, Bansal AR, Jabeen SA, Gopinath S, Jagtap S, Patil S, Suryaprabha T, Jayalakshmi S, Ravat S, Nayak DS. Seizure. 2021 Mar 1;86:60-7.
• Baheti N, Rathore C, Bansal AR, Kannan L, Gopinath S, Pillai A, Jagtap S, Patil S, Jabeen SA, Suryaprabha T, Jayalakshmi S. Current practices in epilepsy monitoring units (EMU) in India. Seizure. 2021 Dec 1;93:13-9.
• AS George, AV Kurup, P Balachandran, M Nair, S Gopinath, A Kumar and H Parasuram, Predicting Autonomic Dysfunction in Anxiety Disorder from ECG and Respiratory Signals Using Machine LearningModels. International Journal of Online & Biomedical Engineering 17 (7), 2021
• H. Parasuram, S. Gopinath, A. Pillai, S. Diwakar and A. Kumar, Quantification of EpileptogenicNetwork From Stereo EEG Recordings Using Epileptogenicity Ranking Method, Front. Neurol., 03 November 2021 | https://doi.org/10.3389/fneur.2021.738111
• Gopinath S., Pillai A., Diwan A.G., Pattisapu J.V., Radhakrishnan K. Reiterating the role of corpuscallosum in generalization of interictal and ictal epileptiform discharges: a case report with post-callosotomy intracranial electroencephalography in Lennox–Gastaut syndrome. Epilepsy and paroxysmal conditions. 2021;13(3):249-253. https://doi.org/10.17749/2077-8333/epi.par.con.2021.086
• Jayapaul P, Gopinath S, Pillai A. Outcome following surgery for insulo- opercular epilepsies. J Neurosurg. 2022 Mar 11:1-11. doi: 10.3171/2021.12.JNS212220. Epub ahead of print. PMID: 35276652.
• Aslam S, Damodaran N, Rajeshkannan R, Sarma M, Gopinath S, Pillai A. Asymmetry index in anatomically symmetrized FDG PET improves epileptogenic focus detection in pharmacoresistant epilepsy. Journal of Neurosurgery, 2022.
• Devisetty R, Amsitha MB, Jyothirmai S, Ajai R, Pillai A, Kumar A, Gopinath S and Parasuram H. Localizing epileptogenic network from SEEG using non-linear correlation, mutual information and graph theory analysis, Journal of engineering in medicine, 2022.
• Shridharani A, Parasuram H, Mrudula B, Bhaskaran R, Kumar A & Gopinath S, Retrospective analysis of autonomic dysfunction in epilepsy patients from neurophysiological recordings, Neurology Asia, 2022.